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KMID : 0043320180410111051
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Archives of Pharmacal Research
2018 Volume.41 No. 11 p.1051 ~ p.1061
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Bioactive enmein-type 6,7-seco-ent-kaurane diterpenoids: natural products, synthetic derivatives and apoptosis related mechanism
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Li Haonan
Sun Baojia
Wang Mingying
Hu Xu
Gao Xiang
Xu Shengtao
Xu Yongnan
Xu Jinyi
Hua Huiming
Li Dahong
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Abstract
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Diterpenoids are important and widely distributed natural compounds with various biological effects, including antitumor, anti-inflammatory and so on. Great efforts have been put in phytochemistry research on diterpenoids. A number of structural modified derivatives and pharmacophore incorporated hybrids were also designed and synthesized with promising therapeutic effects. Among the hopefuls, enmein-type 6,7-seco-ent-kaurane diterpenoids with unique ring system and stereogenic centers exhibit attractive activities. Based on their lead-like properties, enmein-type diterpenoids are suitable for further medicinal study. The derivatives were biologically evaluated and showed promising activities, which warranted in-depth research for further understanding. In this review, the natural bioactive enmein-type diterpenoids and the synthetic derivatives were comprehensively summarized.
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KEYWORD
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Enmein-type, 6,7-seco-ent-kaurane, Diterpenoid, Natural product, Synthetic derivative
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